Simcere is expanding its Boston Innovation Center with a dynamic drug discovery team based in Cambridge, Massachusetts. We are on the lookout for innovative, driven, and autonomous Associate Scientist to enhance our preclinical research division. This role presents an exciting chance to leverage your scientific knowledge in pioneering experiments designed to pinpoint and authenticate novel immunological/oncology targets through both in vitro and in vivo humanized models. As an integral part of our laboratory team, your contributions will significantly influence Simcere’s future pipeline. You’ll have the unique opportunity to engage with various departments within Simcere, playing a pivotal role in drug development from conceptualization to IND filing.

Responsibilities:

Execute cell-based assays to identify potential targets, employing a range of molecular biology techniques tailored to oncology or immunologic disease
Develop and conduct genomic, protein, and cell-based assays for target validation, discovery elucidation, and mechanism of action analysis
Carry out sophisticated multi-color flow cytometry to characterize immune and cancer cells
Execute bioanalytical assays, including ddPCR, ELISA, MSD, and Western Blot, for precise quantification of target proteins
Execute cytotoxicity assay/proliferation assay to examine the functionality of the targets
Independently design experiments, analyze results and present findings with minimal oversight
Collaborate with interdisciplinary teams to propel Simcere’s pipeline forward.
Stay abreast of scientific developments within your field of expertise

Qualifications:

A Bachelor’s or Master’s degree in Cellular Biology, Immunology, Oncology or a related discipline, accompanied by a minimum of two years’ pertinent experience, preferably from the Industry
Proficiency in molecular biology techniques such as cloning, transformation, transfection, transduction, qPCR, gene editing-CRISPR, RNAi, RNA sequencing, NGS and Western blotting
Expertise in cell culture practices, including handling primary cells (e.g., human T and myeloid cells) and established cell lines
A robust foundation in conducting, analyzing, and troubleshooting cellular assays
Training in various cellular assays like flow cytometry, cell proliferation, and immunologicalassays
Exceptional analytical and problem-solving capabilities
Strong communication skills, adept at multitasking, with a commitment to meticulous record-keeping and organization
A self-starter with a team-centric and results-oriented mindset

What Simcere Offers:

A culture fueled by innovation, placing science at the heart of our operations
A vibrant, diverse team of seasoned scientists dedicated to addressing some of the most pressing challenges in human health
A competitive compensation and benefit package, including salary, comprehensive health, dental, vision coverage, long and short-term disability and 401k match

SIMCERE OF AMERICA, INC

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Associate Scientist (Preclinical)