Site Therapeutics aims to map — down to the nucleotide — the genetic determinants driving immune cell function in human health and disease and to use that information to develop first-in-class small molecule therapeutics for autoimmune disease. Leveraging technology developed in the Marson Lab at UCSF/Gladstone, we are conducting high-throughput functional genomics in human cells to build a blueprint for fine-tuned control of immune cell function. This detailed map will lead to the development of new therapeutics across modalities for a range of immune-

related conditions. We are backed by The Column Group, a leading life sciences venture capital

firm.

We are seeking a passionate Scientist / Senior Scientist with a strong interest in adaptive immunology and functional genomics to join our launch team. Our Immunology position will be a part of a team leading efforts to systematically map residues governing disease-relevant phenotypes.

The primary responsibilities of the Scientist / Senior Scientist, Immunology will be:

Prioritization of screening phenotypes in primary immune cells with therapeutic translatability to human autoimmune disease
Development of immunological, biological and biochemical assays to screen and validate novel targets and their associated mechanisms
Optimization of primary human T cell and other lymphocyte or myeloid culture
Flow cytometry and fluorescence-activated cell sorting (FACS) of primary human cells
Design and optimization of high-throughput base editing screens to identify sites on proteins with functional consequences in autoimmune relevant phenotypes
Development of novel protocols and standard operating procedures (SOPs) associated with culturing, differentiating, and screening primary human immune cells
Close collaboration with a team of Scientists and Research Associates to stick to tight timelines while creating a large map of genomic sites impacting immune cells
Stay up-to-date with emerging scientific literature and share your ideas liberally

Strong organizational and communication skills are required. This position represents a unique

opportunity to lead cutting-edge genetic editing research at the frontier of human immunology

and to have an outsized impact on success in the dynamic, rapidly evolving research

environment of an early stage startup.

Qualifications:

Ph.D. in immunology or related field, and 0-3 or more years of laboratory (industrial or postdoctoral) experience
Experience with immunological assay development and flow cytometry and/or FACS, high-throughput preferred
Experience uncovering new mechanisms of action for known immunology-associated targets and/or validating mechanisms of action for novel immunology-associated targets
Experience with mammalian cell culture, primary cells preferred
Excellent organizational and interpersonal communication skills (verbal and written)
Willingness and ability to learn new methods and skills for changing research priorities
Evidence of scientific excellence and impact as illustrated by scientific publications and presentations
Ability to keep detailed and organized records of experimental protocols and results
Ability to work independently and as a member of a research team
Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines
Self-starter with an interest in building a team from the ground up at a brand new start-up

We offer:

In addition to a competitive compensation package with stock options, we offer comprehensive

health, dental, and vision benefits, plus a 401K and 3% employer contribution for employees and their families.

We believe that a diverse, open, and inclusive environment and culture is key to our success.

We will not be influenced in recruiting, hiring, promoting or any other employment practices by

race, color, citizenship status, national origin, ancestry, sex, sexual orientation, gender

identity/expression, age, religion, physical or mental disability, medical or genetic condition,

marital status, veteran status, or any other characteristics protected under applicable federal,

state and local laws. We will make reasonable accommodations for qualified individuals with

known disabilities, in accordance with applicable laws.

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in

place does not create any implied obligation.

Site Therapeutics

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Scientist, Immunology