Description:
The Company:
Larimar Therapeutics Inc. is a publicly held clinical-stage biotechnology company focused on developing treatments for patients suffering from complex rare diseases using its novel cell penetrating peptide technology platform. Our lead product candidate, Nomlabofusp (CTI-1601), is a subcutaneously administered, recombinant fusion protein intended to deliver human frataxin (FXN), an essential protein to the mitochondria of patients with Friedreich's ataxia. Friedreich's ataxia is a rare, progressive, and fatal disease in which patients are unable to produce sufficient FXN due to a genetic abnormality.
We have assembled an experienced management team, each of whom has over 20 years of pharmaceutical industry experience. Our management team, employees, and consultants have significant expertise in discovery, nonclinical and clinical development, regulatory affairs, manufacturing and CMC.
Our company's strategy is to become a leader in the treatment of rare diseases by leveraging our cell-penetrating technology platform and applying our team's know-how to the development of Nomlabofusp and our pipeline projects. We are best characterized by entrepreneurial and scientific leadership and a participatory workforce committed to success.
Position:
Associate Director, Protein Biochemist & Developability
Job Responsibilities:
Position Overview:
We are seeking a talented protein biochemist/biophysicist to join our team as an Associate Director of Protein Biochemistry and Developability. In this role, the successful candidate will play a pivotal role in advancing our understanding and optimization of unique protein therapeutics. The successful candidate will provide build laboratory capabilities and provide hands-on expertise to drive the characterization, engineering, and optimization of protein molecules from early discovery through candidate selection. In this role, your expertise will be critical to: a) partner with our discovery group to design, express, purify, and characterize early candidates and b) partner with our CMC organization to optimize and transfer such protocols for final pipeline candidates. This role is critical in ensuring the developability and manufacturability of protein-based therapeutics, ultimately contributing to the success of our pipeline and the advancement of treatments for patients with rare diseases.
Key Responsibilities:
Protein Characterization and Engineering:
- Design and execute experiments to characterize the biochemical and biophysical properties of protein therapeutics.
- Lead efforts in protein engineering to optimize stability, solubility, and other critical properties.
- Utilize advanced analytical techniques to assess protein structure, function, and interactions.
Developability Assessment:
- Develop and implement assays and methodologies to assess the developability of protein candidates.
- Evaluate factors such as aggregation propensity, immunogenicity, and formulation stability to identify and mitigate risks.
- Work closely with cross-functional teams to integrate developability assessments into the drug development process.
Collaboration and Communication:
- Collaborate closely with colleagues in research, development, and manufacturing to advance protein therapeutic programs.
- Present findings and updates to internal stakeholders and external partners, including scientific conferences and regulatory interactions.
- Contribute to scientific publications and patent applications to communicate novel findings and insights.
Strategic Planning and Project Management:
- Contribute to laboratory planning and budgeting to enable appropriate biochemical and biophysical assessments of pipeline products and critical reagents.
- Establish partnerships with CROs and CDMOs as needed to execute laboratory work.
- Contribute to the strategic planning of protein therapeutic programs, providing scientific expertise and insights.
- Manage project timelines, resources, and budgets effectively to ensure project milestones are met.
- Identify opportunities for process improvements and innovation to enhance efficiency and productivity.
Requirements:
Qualifications:
Ph.D. in Biochemistry, Biophysics, or a related field, with a minimum of 5 years of industry experience in protein biochemistry and developability or M.S. in related fields with a minimum of 10 years experience.
Demonstrated expertise in protein purification and characterization techniques, such as chromatography, dynamic light scattering, mass spectrometry, and spectroscopy.
Proven track record of leading successful protein engineering and optimization efforts.
Strong understanding of protein structure-function relationships and biophysical properties.
Experience in developability assessment and formulation development for protein therapeutics is highly desirable.
Excellent leadership and communication skills, with the ability to inspire and motivate a multidisciplinary team.
Strategic thinking and problem-solving abilities, with a focus on driving projects forward in a fast-paced, dynamic environment.
Benefits:
Larimar Therapeutics offers all employees incentive stock options, a comprehensive benefits plan including 401K, and a flexible PTO policy.
We are committed to equal-employment principles, and we recognize the value of committed employees who feel they are being treated in an equitable and professional manner. We strive to find ways to attract, develop and retain the talent needed to meet business objectives, and to recruit and employ highly qualified individuals representing the diverse communities in which we live.
Employment policies and decisions on employment and promotion are based on merit, qualifications, performance, and business needs. The decisions and criteria governing the relationship with all candidates and employees are made in a non-discriminatory manner—without regard to age, race, color, national origin, gender (including pregnancy, childbirth or medical condition related to pregnancy or childbirth), gender identity or expression, religion, physical or mental disability, medical condition, legally protected genetic information, marital status, veteran status, military status, sexual orientation, or any other factor determined to be an unlawful basis for such decisions by federal, state, or local statutes.
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