JOB TITLE: Associate Scientist, mRNA Platform Process Development
Location: Seattle, WA (100% Onsite)
Duration: 12 months initial (potential extension/potential right to hire)
Top Skills:
• Proficiency in generating and interpreting qPCR and RT-PCR data sets
• Proficiency with capillary electrophoresis (preferred Sciex PA800 Plus system), Agarose gel electrophoresis, and/or TapeStation analysis
• Proficiency with ELISA workflows
• Experience working with, storing, and analyzing purified nucleic acids
Seeking a highly motivated Associate Scientist to work in a fast-paced P&AD environment applying rigorous scientific principles towards developing a platform process for producing mRNA. As a part of the Gene Delivery and Editing Process Development (GDEPD) organization, the ideal Associate will possess sufficient experience in analytical method development of biological molecules, with a high preference for any experience with developing analytical methods for measuring mRNA impurities, quality attributes, and expression in cells.
A successful Associate will directly employ biophysical, analytical, and cell assay techniques to develop our next-generation gene edited therapies. In this capacity, the Associate will design and execute analytical methods for mRNA molecules to enable robust ex vivo studies. An outstanding candidate will be driven by a desire to create, optimize, and define processes with speed in a collaborative environment.
Key Responsibilities:
• Execute and troubleshoot analytical assays for the characterization of mRNA molecules
• Assist in the design, and evaluate the performance, of new analytical development assays
• Assist in establishing SOPs and protocols for analytical assays
• Manage samples and data related to mRNA platform process development
• Optimize workflows for assessing mRNA attributes and impurities
• Provide experimental design and executional support to team members in adjacent and related functions (e.g. clinical development programs, high throughput process development, etc.)
• Actively participate and support lab maintenance and continuous improvement initiatives
• Maintain accurate and detailed laboratory notebook and documentation
• Summarize and present data in group meetings and contribute to group discussions
• Author technical reports, study memos, and protocols
Basic Qualifications:
• STEM degree with 2+ years of relevant industry experience; title/compensation will be commensurate with education, experience, and skillset
• Proficiency in generating and interpreting qPCR and RT-PCR data sets
• Proficiency with capillary electrophoresis (preferred Sciex PA800 Plus system), Agarose gel electrophoresis, and/or TapeStation analysis
• Proficiency with ELISA workflows
• Experience working with, storing, and analyzing purified nucleic acids
• Independently motivated with the ability to work in teams
• Ability to communicate clearly and concisely through oral presentation and technical writing
• Ability to leverage literature, internal and external resources to solve problems and develop new technologies
• Possess a growth mindset and the ability to thrive in a fast-paced, highly collaborative environment
Preferred Qualifications:
• Degree in biological or chemical engineering, biochemistry, or bio-related field
• Experience with IP-RP-UPLC method development
• Experience with JMP for DoE design and analysis
• Experience with the in vitro transcription of mRNA
• Experience interacting and collaborating with vendors
• Experience with collecting, organizing, and interpreting large data sets
• Experience with mammalian cell-based assays which include flow cytometric readouts
Additional Job Requirements:
Lab w/o blood & animal
If hired, you will enjoy the following Eclaro Benefits:
- 401k Retirement Savings Plan administered by Merrill Lynch
- Commuter Check Pretax Commuter Benefits
- Eligibility to purchase Medical, Dental & Vision Insurance through Eclaro
If you feel you are qualified with the required skills and if you are interested, please free to send your word version most updated resume TAILORED to the job description above to June@eclaro.com or call (212)804-7476.
Equal Opportunity Employer: Eclaro values diversity and does not discriminate based on Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status.
