HDT Bio is pioneering technologies that direct the host immune system to treat or prevent cancer and infectious diseases. This Postdoctoral Scientist – Virology Team will be primarily responsible for designing and executing experiments in discovery- and application-based projects utilizing HDT’s RNA vaccine platform to develop vaccines and therapeutics against emerging viral pathogens.
They will specifically contribute towards 1) advanced understanding of mucosal immune responses generated by HDT’s RNA vaccine platform, 2) identification of opportunities to leverage HDT’s RNA vaccine platform against emerging respiratory pathogens, and 3) leading key pre-clinical studies to advance candidate therapeutics towards human clinical trials. A successful candidate should have expertise in studying mucosal immune responses to vaccines and the pathogenesis of respiratory virus infection. The ideal candidate will have extensive laboratory experience characterizing adaptive immune responses (both cellular and humoral) within mucosal tissues. Applicants with experience working with influenza viruses are highly encouraged to apply. This candidate should be able to characterize mucosal antibody responses, identify and immunophenotype tissue resident memory cells, and possess an in-depth understanding of phenotypes associated with protective mucosal immune responses. The candidate should also have expertise in supporting collaborative projects and prioritize accurate and thorough communication of research findings to diverse stakeholders. Their scientific subject-area expertise, know-how, and critical thinking will ensure project success and help foster a culture of collaboration, innovation, and scientific excellence in our team.
Despite this being a postdoctoral position, applicants who already have postdoctoral experience are encouraged to apply.
Candidates are encouraged to send cover letters to the hiring team by emailing barbara.purmort@hdt.bio
To see a list of recent publications from our team, please see: Publications - HDT Bio
Principal Responsibilities:
- Perform in vitro and in vivo studies to advance understanding of tissue-specific immune responses to HDT’s RNA vaccine platform
- Contribute to achieving company goals as a team player
- Demonstrate fundamental mucosal immunology, virology, and immunobiology techniques and knowledge to advance project goals
- Keep detailed records of experimental methods and author reports that support regulatory submissions
- Contribute and author scientific publications in peer-reviewed journals
Qualifications:
- Experience with mucosal immunology techniques relevant to understanding vaccine immunogenicity, including but not limited to:
- Multiparameter (10+ color) flow cytometry and FACS
- Histology (IHC, RNAScope, IFA)
- ELISA
- ELISpot
- Intracellular cytokine staining
- Multiplex cytokine assays
- Ideally, the applicant will possess expertise in virology and respiratory viruses. Experience with influenza virus is highly preferred. Knowledge of associated techniques such as virus propagation, virus titration, neutralization assays, pseudotyped viruses, viral RNA quantification and viral protein expression is a plus.
- Expertise in small rodent handling and associated experimental techniques for evaluating host immune responses to vaccines and therapies.
- Publication record in peer-reviewed journals.
- Demonstrated ability to troubleshoot scientific problems with appropriately designed experimentation
- Scientific creativity, collaborative ability, management of a research team and excellent written and verbal communication skills
Education/Experience:
- Ph.D. in virology, immunology, vaccinology, or related field
- 0-2 years of relevant industry or postdoctoral experience.
This summary describes a portion of the essential functions/responsibilities of this position. It is not an exhaustive list of all job duties. Management reserves the right to modify the duties of this position as necessary.
HDT Bio is a vaccine and immunotherapy Biotechnology company with next-generation approaches designed to enable the body’s immune system to prevent and cure disease. We have engineered our technologies to Access, Activate, and Amplify the immune system’s natural ability to create antibodies and T-cells that fight cancer and infectious diseases such as SARS-CoV-2. We are developing multiple product candidates from our proprietary discovery platforms, including LION™, which has the potential to provide health benefits to a broad patient population.
HDT Bio offers a comprehensive compensation plan which includes health insurance for employees and dependents (inclusive of multiple plants to choose from, including a $0 premium plan with HSA and company contribution), generous PTO (11 observed holidays and week-long year-end closure), stock options with Carta Tax Advisory for equity and tax support, flexible spending accounts (FSAs), commuting benefits (ORCA or paid parking), and retirement benefits with company match.
HDT Bio Corp. is an equal opportunity employer committed to a diverse and inclusive workforce. This environment is encouraged by HDT's culture, which supports women in science through our Women+ group, creates inclusive events to highlight the diverse cultures represented by our staff, and with the adoption of an open office environment for all. Qualified applicants of any race, color, religion, sex, sexual orientation, gender identity, age, national origin, veteran, or disability status are encouraged to apply. Applicants will be considered for employment without regard to these or any other actual or perceived statuses.
