Associate Director-Diabetes & Obesity Biology

BioPhase • san francisco, ca, us • 2m ago

Associate Director-Diabetes & Obesity Biology

Key Responsibilities:

Serve as the Diabetes & Obesity Biology lead on multiple project teams; conduct and troubleshoot experiments, analyze and interpret data, and work cross-functionally with colleagues to identify and mitigate risks and effectively advance therapeutic programs.
Design and execute in vitro and ex vivo studies to advance therapeutic programs.
Generate, analyze, and interpret complex data to establish functional PK/PD and efficacy relationships and elucidate therapeutic mechanisms of action for lead drugs.
Develop and enhance complex in vitro and ex vivo research and development capabilities.
Author and review protocols, study reports, and regulatory documents to support IND and other regulatory filings.
Adhere to all company policies and practices, maintaining accurate records and notebooks.

Experience:

PhD in Immunology/Inflammation, Metabolic Disease, Physiology, Diabetes/Obesity, or a related biological science (MSc with relevant years of experience).
At least 7 years of direct hands-on experience in therapeutic development using indication-specific functional disease models in the biotechnology and pharmaceutical industries (MSc with at least 10 years).
Experience with therapeutic programs that have yielded drugs entering clinical development in endocrinology, diabetes/obesity, immunology/inflammation, or metabolic disease.
Proficiency with cell-based assays, ELISA, MSD, qPCR, RNA-seq, microscopy, histology/pathology (e.g., IF/IHC/ISH), and/or flow cytometry.
Ability to work hands-on in the lab, manage scientists, write protocols, and execute studies using in-house capabilities or in collaboration with CROs.
Direct experimental experience with the complex disease biology of diabetes, obesity, or other metabolic diseases.
Expertise in building PK/PD and efficacy relationships with complex 2D/3D functional cell-based and tissue-based assays.
Experience leveraging complex data sets to characterize therapeutic leads and establish therapeutic mechanisms of action.
Experience leading project teams with functional responsibility to propose strategies, analyze, interpret, and present complex data to inform decisions.
Proficiency in collaborating on writing protocols, reports, and regulatory documents.
Experience working with vendors and CROs to execute studies, analyze data, and generate reports in a timely manner.
Experience authoring study protocols, reports, and regulatory documents including IBs, IND filings, CSRs, and NDAs.
Outstanding communication skills with the ability to make effective presentations in various settings.
Detail-oriented and organized, with strong interpersonal skills for clear and effective communication.
Experience with microscopy, confocal imaging, or similar techniques is a plus.
Experience as a subject matter expert with complex cell-based 2D/3D culture systems, ex vivo tissue models, or patient-derived samples is a plus.
Ability to generate, analyze, and interpret multi-omic data sets.
Experience establishing workflows, using platforms like Jupyter Notebook for bioinformatics analysis, and interpreting and visualizing complex data sets is a plus.
Previous experience leading a program in therapeutic discovery/development.
Strong statistical analysis skills with the ability to articulate findings and make recommendations based on complex study results.
Experience mentoring scientists, leading cross-functional project teams, and successfully managing external teams.

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