Job Overview:
We are seeking a skilled and detail-oriented Microscopy Technician to join our team. This Scientist will operate and maintain various microscopy systems, including microtomes, Scanning Electron Microscopy (SEM), light microscopy, PCR and Microplate Readers systems, Electrophoresis, fluorescence microscopy.
You will be responsible for preparing and analyzing samples, operating and maintaining microscopy equipment, and assisting with data analysis to support our research and product development efforts.
Key Responsibilities:
Histology
- Perform tissue fixation, dissection, clearing, sectioning, mounting, staining, and covering of tissue sections on microscope slides. This includes paraffin tissue processing, embedding, and microtomy.
- Perform precise sectioning of biological tissues using a microtome, including paraffin and frozen sections.
- Ensure proper alignment and thickness of sections for downstream analyses (staining, microscopy, etc.).
- Ensure consistent quality and reproducibility of tissue sections for diagnostic or research purposes.
- Conduct standard tissue labeling techniques such as hematoxylin and eosin (H&E), silver stain, DAPI, immunohistochemistry, and in-situ hybridization.
- Experience with routine histology procedures and immunohistochemistry is a plus.
- Knowledge of histopathology and tissue anatomy.
- Familiarity with identifying tissue organs/samples, microtomy skills, and routine hematoxylin and eosin staining is preferred.
- Familiarity with preparing buffers and solutions, as well as experience using a microtome, clearing tissue instrument, slide scanner, and cryostat.
General
- A problem-solver who thrives on troubleshooting and finding solutions to technical challenges.
- Experience maintaining lab spaces and equipment (e.g., cleaning beakers, calibrating equipment, logging materials).
- Ability to interpret Safety Data Sheets and Certificates of Analyses
- Ability to do scientific mathematical calculations such conversions, dilutions, etc..
- Strong time management skills, ability to work within time constraints, and handle multiple projects with precision. Highly organized with strong attention to detail.
- Prepare routine solutions and buffers for the team and researchers to use in the laboratory.
- Read and follow established protocols, write new protocols, assist in optimizing protocols for new techniques and tissue types, and ensure detailed documentation of all work performed.
- Maintain and document the use and upkeep of laboratory equipment. Troubleshoot equipment and resolve issues to minimize downtime.
- Maintain a safe, clean, and orderly laboratory environment, including handling hazardous chemicals, disposing of waste, managing inventory, and ordering supplies.
- Ensure accurate written and computerized records are maintained, analyze raw data collection, and address deviations from SOPs or protocol requirements.
- Perform routine lab duties, such as inventory management, ordering supplies, cleaning equipment, and glassware.
- Handle sensitive intellectual property (IP) and data with care.
- Perform routine maintenance and calibration of microscopes and PCR equipment.
- Follow all laboratory safety guidelines and proper handling protocols.
- Troubleshoot equipment issues and coordinate repairs with technical support as needed.
- Follow all laboratory safety guidelines and proper handling protocols.
- Performs additional duties as assigned.
- Use ELN system to document day-to-day work and Lab Reports
- Proficient in Microsoft Office and basic laboratory techniques (e.g., pH measurement, centrifugation).
Preferred Skills:
Biology, Equipment Maintenance, Histology, Microtome, Quality Control, Reagents, Slide Preparation, Staining, Tissue Processing, Tissue, Laboratory Skills, Communication, Cryostat, Dexterity, Mounting, Project Leadership, Data Collection, Light Microscopy, Fluorescence/Confocal Microscopy, Electron Microscopy, SEM, TEM, Data Collection, Record Keeping, Laboratory Safety, Reagents, Test Analysis
Additional Compensation with these skills:
- Assist in preparing live and fixed slides for cells and Extracellular vesicles
- Performing 3d cell culture imaging
- Experience with PCR techniques from sample prep to result interpretation.
- Knowledge of advanced microscopy techniques (confocal, fluorescence, super-resolution microscopy, scanning/transmission electron microscopy)
- Prepare samples for SEM analysis using various techniques such as sputter coating, ion milling, or cryo-SEM, ensuring samples are properly prepared for accurate imaging and data acquisition.
- Prepare samples and conduct structural characterization of biological specimens, including tissues, cells, and extracellular vesicles, utilizing electron microscopy techniques.
Perks:
- Competitive salary and benefits package.
- Flexible working hours and remote working opportunities.
- A creative, dynamic team and an exciting work environment.
- Opportunities for growth and skill development.
