Biotechnology company is hiring a full-time Senior Scientist to contribute to process characterization efforts to support pipeline programs. The candidate will be responsible for preparation, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates. You will have significant laboratory experience and an excellent understanding of analytical chemistry principles. The successful candidate will be expected to design, execute, and troubleshoot experiments with minimal guidance. The candidate will also contribute to analytical development and stability studies. Responsibilities will additionally include record management, data presentation at group meetings, authorship of laboratory protocols and development reports, communication with external organizations during tech transfer, and assumption of a leadership role in collaborative studies.
Responsibilities
- Optimize and troubleshoot multi-step syntheses of protein-polysaccharide conjugates.
- Purify polysaccharides and conjugates using a variety of methods including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF).
- Analyze polysaccharides and conjugates with a variety of analytical methods. Develop new laboratory workflows and analyses beyond established procedures when appropriate.
- Advise team members on experimental design, interpretation of results, and troubleshooting.
- Model and train team members on best practices for adherence to protocols and data management.
- Serve as a subject matter expert during tech transfer of conjugation processes to contract manufacturing organizations.
- Maintain highly organized records to enable optimization and assessment of reproducibility.
- Attend team meetings ready to provide updates on conjugation development progress.
Qualifications
- PhD in chemistry or biochemistry and 2-5+ years of industry experience, MS with 5-8+ years, or BS with 10+ years of experience.
- Strong biochemistry and organic chemistry knowledge base underpinning several years’ experience preparing bioconjugates.
- Proficiency with small- and large-scale techniques for purification of bioconjugates, including tangential flow filtration.
- Proficiency in a variety of techniques for bioconjugate analysis such as colorimetric assays, HPLC, and SEC-MALS.
- Sufficient knowledge of analytical principles to develop fit-for-purpose analytical methods as needed and provide cross-functional feedback on draft analytical methods.
- Experience with Design of Experiments is desirable.
- Experience with chemical modification of polysaccharides is desirable.
- Experience implementing and/or using electronic notebooks is desirable.
- Self-starter; ability to work in a fast-paced, cross-functional environment and collaborate effectively with other team members.
- Enthusiasm to learn the new skills and techniques necessary to tackle problems outside of current area of expertise.
Salary
R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering. We provide job opportunities within major pharmaceutical, biopharmaceutical, biotechnology, and medical device companies.
R&D Partners is an equal-opportunity employer.