Job description: Senior Research Associate, Nanoparticle Formulation
Who We Are
Rampart Bioscience is an early-stage biotechnology company pioneering a new class of medicines for individuals, especially children, living with genetically driven diseases.
Powered by its non-viral DNA delivery platform, Rampart’s mission is to develop transformative medicines that achieve higher standards for potency and safety than current gene therapies. Rampart Bio is funded by several global, top-tier healthcare investment firms, and is led by seasoned experts in gene delivery, protein sciences, and clinical translation.
When you join Rampart, you are not simply advancing your career. You are joining a team that is dedicated to realizing the potential of gene therapy to provide effective, safe, and long-lasting treatments for a wide range of diseases. We are mission-driven and guided by our values:
- People first. Nothing shall be done to harm human dignity or get in the way of one’s freedom.
- Unbound by convention. We embrace the unfamiliar and are willing to stand alone together.
- Actions speak. We have a bias for action and serve with humility as we work to achieve new ground.
- Relationships matter. We build authentic relationships founded on trust, integrity, diligence, and honor.
- We care. We are disciplined and passionate. We love what we do, who we do it with, and who we do it for.
As we advance our work in exciting ways, we are selectively hiring talented team members to join us in our Southern California locations. For more information, please visit www.rampartbio.com.
About the Job
In this role, the successful candidate will partner with the Nanoparticle Formulation team to perform formulations of Rampart Bio’s proprietary nucleic acid with lipids, polymers or hybrids.
This role requires a high level of organization and attention-to-details to coordinate and execute experiments. Under minimal supervision, this candidate will provide skilled handling raw materials, formulation process, downstream processing, physico-chemical analysis of nucleic acid and lipid/polymer nanoparticles and data analysis. The candidate will be required to prepare organized protocols, electronic notebook notes and reports.
The ideal candidate will have broad soft nanoparticle formulation experience, especially LNPs, liposomes and polymers., with a collaborative spirit, a sense of urgency, and a desire to work in a fast-paced startup environment.
This role offers the opportunity to work on cutting-edge projects that have the potential to impact patient outcomes.
Key Responsibilities
- Assist in design and formulation of lipid-based (LNP, Liposomes) and/or polymer nanoparticles with DNA and mRNA.
- Assist in formulation optimizations such as compositional screens and manufacturing process development activities to develop safe and effective formulations.
- Conduct and interpret physico-chemical characterization of LNP, liposome and polymer nanoparticles via DLS, Zeta potential, TNS, Pico- or Ribogreen, or other specialized assays as needed.
- Assist in developing and documenting procedures, such as formulation protocols, SOPs, Raw materials inventory building.
- Maintain a detailed, accurate, and up-to-date electronic laboratory notebook, controlled substances log, and sample inventory database, as needed.
- Prepare summary reports and present to stakeholders.
- Assist in lab organization and maintenance, sample inventory management, coordination of shipments, and supply ordering.
- Train junior staff as needed.
Qualifications/Requirements
- BS degree and 2-3 years of relevant formulation experience or MSc with 1-2 yrs.
- Ability to work directly with reagents, buffers, different lipids and nucleic acids.
- Skill in formulation, downstream processing of LNPs, liposomes and polymer nanoparticles
- Experience with microfluidic LNP and polymer nanoparticle manufacturing.
Desirable Skills and Experience
- Expertise working with a variety of formulations.
- A high degree of attention to detail and concern for properly conducting experiments and assigned tasks.
- Ability to troubleshoot and think analytically.
- Strong work ethic and a collaborative team player.
- Good interpersonal skills and effective communication, both verbal and written.
- Ability to multitask and support multiple projects simultaneously.
- A strong sense of urgency and accountability.
Compensation, Benefits & Additional Information
Compensation range: $78,000 - $90,000 commensurate with experience and qualifications. We are proud to provide a robust benefits package for our employees, including:
Medical, dental and vision insurance for employees and their dependents, with a 90% - 100% company contribution.
Life, AD&D and disability insurance for employees, with a 100% company contribution.
401(k).
Generous amounts of paid time off through our vacation, holiday, sick and floating time off
programs including floating “beach” days and your birthday off.
Ability to participate in the company’s Stock Benefit Plan and annual Bonus Plan.
Please attach a cover letter with your resume explaining your experience with Nanoparticle Formulation and or research within the biomedical field, and why you would be a good fit for Rampart Biomedical Inc.
Rampart Bioscience is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, sexual orientation, national origin, disability, age, veteran status or any other applicable legally protected characteristics
